Trismus in patients with oropharyngeal cancer: Relationship with dose in structures of mastication apparatus
- 22 January 2008
- journal article
- research article
- Published by Wiley in Head & Neck
- Vol. 30 (5), 622-630
- https://doi.org/10.1002/hed.20760
Abstract
Background Our aim was to assess the correlation between the radiation therapy (RT) dose to the mastication apparatus and trismus of oropharyngeal cancer patients. Methods Eighty-one patients treated with RT were analyzed. The masseter, pterygoid, and temporalis muscles and the coronoid and condyl were delineated on axial CT slices. The mean dose in these structures was correlated with outcome of quality of life questionnaires. Results Fifty-six (88%) patients responded; 16% of the patients scored grade 3/4 on the Head & Neck 35 “opening mouth” question. A significant correlation was observed between dose in masseter and pterygoid muscles and trismus (p = .02). Conclusion Patients treated with brachytherapy received a lower dose in masticatory muscles. A steep dose-effect relationship between mean dose in masseter muscle and pterygoid muscles and the probability of having trismus complaints was observed; with every additional 10 Gy to the pterygoid muscle, an increase of the probability of trismus of 24% was observed. © 2008 Wiley Periodicals, Inc. Head Neck, 2008Keywords
This publication has 27 references indexed in Scilit:
- Exercise therapy for trismus in head and neck cancerOral Oncology, 2007
- Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysisThe Lancet, 2006
- Criteria for trismus in head and neck oncologyInternational Journal of Oral & Maxillofacial Surgery, 2006
- Proposal for the delineation of the nodal CTV in the node-positive and the post-operative neckRadiotherapy and Oncology, 2006
- Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and NeckNew England Journal of Medicine, 2006
- The Degree and Time‐Course Assessment of Radiation‐Induced Trismus Occurring After Radiotherapy for Nasopharyngeal CancerThe Laryngoscope, 2005
- Trismus in head and neck oncology: a systematic reviewOral Oncology, 2004
- Dose escalation using twice-daily radiotherapy for nasopharyngeal carcinoma: does heavier dosing result in a happier ending?International Journal of Radiation Oncology*Biology*Physics, 2002
- A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patientsEuropean Journal Of Cancer, 2000
- An intraoral positive-pressure device for treatment of trismusOral Surgery, Oral Medicine, Oral Pathology, 1986