Cell death inStreptococcus mutans  biofilms: a link between CSP and extracellular DNA
Open Access
- 1 October 2009
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 299 (2), 261-266
- https://doi.org/10.1111/j.1574-6968.2009.01758.x
Abstract
Streptococcal competence-stimulating peptides (CSPs) were once thought to passively communicate population density in a process known classically as quorum sensing. However, recent evidence has shown that these peptides may also be inducible ‘alarmones,’ capable of conveying sophisticated messages in a population including the induction of altruistic cellular suicide under stressful conditions. We have previously characterized the alarmone response in Streptococcus mutans, a cariogenic resident of the oral flora, in which a novel bacteriocin-like peptide causes cell death in a subset of the population. Our objective in this work was to characterize the mechanism of immunity to cell death in S. mutans. Toward this goal, we have identified the conditions under which immunity is induced, and identified the regulatory system responsible for differential (and protective) expression of immunity. We also showed that CSP-induced death contributes to S. mutans biofilm formation through the release of chromosomal DNA into the extracellular matrix, providing a long sought-after mechanistic explanation for the role of CSP in S. mutans biofilm formation.Keywords
This publication has 31 references indexed in Scilit:
- Peptide alarmone signalling triggers an auto‐active bacteriocin necessary for genetic competenceMolecular Microbiology, 2009
- The LiaFSR System Regulates the Cell Envelope Stress Response inStreptococcus mutansJournal of Bacteriology, 2009
- Involvement ofStreptococcus mutansregulator RR11 in oxidative stress response during biofilm growth and in the development of genetic competenceLetters in Applied Microbiology, 2008
- The EPS Matrix: The “House of Biofilm Cells”Journal of Bacteriology, 2007
- Systemic inactivation and phenotypic characterization of two-component systems in expression of Streptococcus mutans virulence propertiesLetters in Applied Microbiology, 2007
- The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureusProceedings of the National Academy of Sciences of the United States of America, 2007
- Cell density- and ComE-dependent expression of a group of mutacin and mutacin-like genes in Streptococcus mutansFEMS Microbiology Letters, 2006
- Sociomicrobiology: the connections between quorum sensing and biofilmsTrends in Microbiology, 2005
- Two-Component Signal TransductionAnnual Review of Biochemistry, 2000
- THINKING ABOUT BACTERIAL POPULATIONS AS MULTICELLULAR ORGANISMSAnnual Review of Microbiology, 1998