Interferon regulatory factor‐2 induces megakaryopoiesis in mouse bone marrow hematopoietic cells
- 8 October 2009
- journal article
- Published by Wiley in FEBS Letters
- Vol. 583 (21), 3493-3500
- https://doi.org/10.1016/j.febslet.2009.10.006
Abstract
Megakaryopoiesis is associated with inflammatory reactions. To investigate the role of interferon regulatory factors (IRFs) in inflammation-associated megakaryopoiesis, mouse bone marrow hematopoietic stem cells (HSCs) were analyzed. IFN-γ treatment induced IRF-2 expression as well as the expression of CD41 and IRF-1 in HSCs. An in vitro clonogenic assay showed that IRF-2- but not IRF-1-overexpressing cells increased the number of megakaryocytic colonies. IRF-2 transfection up-regulated CD41 promoter activity in hematopoietic cell lines. The number of CD41-positive bone marrow cells increased in mice injected with IRF-2-expressing bone marrow cells. These findings suggest that IRF-2 plays an important role in megakaryopoiesis in inflammatory statesKeywords
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