An Organoselenium Compound Inhibits Staphylococcus aureus Biofilms on Hemodialysis Catheters In Vivo
Open Access
- 1 February 2012
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 56 (2), 972-978
- https://doi.org/10.1128/aac.05680-11
Abstract
Colonization of central venous catheters (CVCs) by pathogenic bacteria leads to catheter-related bloodstream infections (CRBSIs). These colonizing bacteria form highly antibiotic-resistant biofilms. Staphylococcus aureus is one of the most frequently isolated pathogens in CRBSIs. Impregnating CVC surfaces with antimicrobial agents has various degrees of effectiveness in reducing the incidence of CRBSIs. We recently showed that organoselenium covalently attached to disks as an antibiofilm agent inhibited the development of S. aureus biofilms. In this study, we investigated the ability of an organoselenium coating on hemodialysis catheters (HDCs) to inhibit S. aureus biofilms in vitro and in vivo . S. aureus failed to develop biofilms on HDCs coated with selenocyanatodiacetic acid (SCAA) in either static or flowthrough continuous-culture systems. The SCAA coating also inhibited the development of S. aureus biofilms on HDCs in vivo for 3 days. The SCAA coating was stable and nontoxic to cell culture or animals. This new method for coating the internal and external surfaces of HDCs with SCAA has the potential to prevent catheter-related infections due to S. aureus .This publication has 35 references indexed in Scilit:
- Prevention of catheter-related bloodstream infection in patients on hemodialysisNature Reviews Nephrology, 2011
- Antimicrobial and antibiofilm efficacy of triclosan and DispersinB(R) combinationJournal of Antimicrobial Chemotherapy, 2009
- A systematic review comparing the relative effectiveness of antimicrobial-coated catheters in intensive care unitsAmerican Journal of Infection Control, 2008
- Cluster of Pseudomonas aeruginosa catheter-related bloodstream infections traced to contaminated multidose heparinized saline solutions in a medical wardInternational Journal of Hygiene and Environmental Health, 2006
- Central Venous Catheter Colonization in Critically Ill Patients: A Prospective, Randomized, Controlled Study Comparing Standard with Two Antiseptic-Impregnated CathetersAnesthesia & Analgesia, 2005
- Reduction of catheter-related infections in neutropenic patients: a prospective controlled randomized trial using a chlorhexidine and silver sulfadiazine-impregnated central venous catheterAnnals of Hematology, 2004
- Comparison of bacterial colonization rates of antiseptic impregnated and pure polymer central venous catheters in the critically illJournal of Hospital Infection, 2002
- Biofilms: Survival Mechanisms of Clinically Relevant MicroorganismsClinical Microbiology Reviews, 2002
- The Involvement of Cell-to-Cell Signals in the Development of a Bacterial BiofilmScience, 1998
- Prevention of Catheter-Related Infections by Antiseptic BondingJournal of Surgical Research, 1993