Changing biology of cutaneous melanoma
- 1 June 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Melanoma Research
- Vol. 18 (3), 225-229
- https://doi.org/10.1097/cmr.0b013e3282f94651
Abstract
Survival of patients with cutaneous melanoma (CM) has improved significantly worldwide despite moderate treatment changes. The aim of our study was to determine whether the time period of diagnosis was an independent prognostic factor. The data of 1752 patients diagnosed with CM in Slovenia between 1983 and 1997 were analyzed. Cox proportional hazards model was used to assess the effect of multiple variables on survival. No significant decrease was observed in mean tumor thickness, whereas mean age at the time of diagnosis increased from 36.58 to 53.32 years. Multivariate analysis confirmed tumor thickness, age at the time of diagnosis, regional metastases and period of diagnosis as independent predictors of survival (P<0.0001). The most important independent predictor of survival of patients diagnosed with CM in the time period from 1983 to 1997 was the time of diagnosis.Keywords
This publication has 15 references indexed in Scilit:
- Malignant Melanoma in the 21st Century, Part 1: Epidemiology, Risk Factors, Screening, Prevention, and DiagnosisMayo Clinic Proceedings, 2007
- Incidence, mortality and survival in cutaneous melanomaJournal of Plastic, Reconstructive & Aesthetic Surgery, 2007
- Improvement of overall survival of patients with cutaneous melanoma in Germany, 1976–2001Cancer, 2007
- Distinct Sets of Genetic Alterations in MelanomaThe New England Journal of Medicine, 2005
- Sun Exposure and Mortality From MelanomaJNCI Journal of the National Cancer Institute, 2005
- The Australian experience in sun protection and screening for melanomaJournal of Surgical Oncology, 2004
- A critical analysis of reasons for improved survival from invasive cutaneous melanoma.Cancer Causes & Control, 2003
- Changing epidemiology of malignant cutaneous melanoma in Europe 1953–1997: Rising trends in incidence and mortality but recent stabilizations in Western Europe and decreases in ScandinaviaInternational Journal of Cancer, 2003
- Vitamin D, Cod-Liver Oil, Sunlight, and Rickets: A Historical PerspectivePEDIATRICS, 2003
- Final Version of the American Joint Committee on Cancer Staging System for Cutaneous MelanomaJournal of Clinical Oncology, 2001