Genetic Contributions to Long-Range Temporal Correlations in Ongoing Oscillations
Open Access
- 12 December 2007
- journal article
- research article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 27 (50), 13882-13889
- https://doi.org/10.1523/jneurosci.3083-07.2007
Abstract
The amplitude fluctuations of ongoing oscillations in the electroencephalographic (EEG) signal of the human brain show autocorrelations that decay slowly and remain significant at time scales up to tens of seconds. We call these long-range temporal correlations (LRTC). Abnormal LRTC have been observed in several brain pathologies, but it has remained unknown whether genetic factors influence the temporal correlation structure of ongoing oscillations. We recorded the ongoing EEG during eyes-closed rest in 390 monozygotic and dizygotic twins and investigated the temporal structure of ongoing oscillations in the alpha- and beta-frequency bands using detrended fluctuation analysis (DFA). The strength of LRTC was more highly correlated in monozygotic than in dizygotic twins. Statistical analysis attributed up to ∼60% of the variance in DFA to genetic factors, indicating a high heritability for the temporal structure of amplitude fluctuations in EEG oscillations. Importantly, the DFA and EEG power were uncorrelated. LRTC in ongoing oscillations are robust, heritable, and independent of power, suggesting that LRTC and oscillation power are governed by distinct biophysical mechanisms and serve different functions in the brain. We propose that the DFA method is an important complement to classical spectral analysis in fundamental and clinical research on ongoing oscillations.Keywords
This publication has 49 references indexed in Scilit:
- High Gamma Power Is Phase-Locked to Theta Oscillations in Human NeocortexScience, 2006
- Genetic influences on dynamic complexity of brain oscillationsNeuroscience Letters, 2006
- On the human sensorimotor-cortex beta rhythm: Sources and modelingNeuroImage, 2005
- Frequency and dependence of long range temporal correlations in human hippocampal energy fluctuationsComplexity, 2005
- Hippocampal sequence-encoding driven by a cortical multi-item working memory bufferTrends in Neurosciences, 2005
- Long-range temporal correlations in alpha and beta oscillations: effect of arousal level and test–retest reliabilityClinical Neurophysiology, 2004
- Theory and Practice in Quantitative GeneticsTwin Research, 2003
- Effect of nonstationarities on detrended fluctuation analysisPhysical Review E, 2002
- Dynamic predictions: Oscillations and synchrony in top–down processingNature Reviews Neuroscience, 2001
- Dynamical representation of odors by oscillating and evolving neural assembliesTrends in Neurosciences, 1996