High performance photosensitizers with aggregation-induced emission for image-guided photodynamic anticancer therapy
- 18 August 2017
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Mater. Horiz.
- Vol. 4 (6), 1110-1114
- https://doi.org/10.1039/c7mh00469a
Abstract
A series of D–A′–π–A type photosensitizers, AP3 and AP4, were designed and synthesized to show strong aggregation-induced far red and near infrared emission and very effective 1O2 generation simultaneously. In comparison with the most widely used photosensitizer, Ce6 nanoparticles, AP4 nanoparticles showed over 10-fold higher fluorescence quantum yield, and more than 3-fold higher 1O2 generation efficiency, and have been successfully used for image-guided photodynamic anticancer therapy.Funding Information
- National Natural Science Foundation of China (51622305, 81220108015)
- National University of Singapore (R279-000-482-133)
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