Circadian Disorganization Alters Intestinal Microbiota
Top Cited Papers
Open Access
- 21 May 2014
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 9 (5), e97500
- https://doi.org/10.1371/journal.pone.0097500
Abstract
Intestinal dysbiosis and circadian rhythm disruption are associated with similar diseases including obesity, metabolic syndrome, and inflammatory bowel disease. Despite the overlap, the potential relationship between circadian disorganization and dysbiosis is unknown; thus, in the present study, a model of chronic circadian disruption was used to determine the impact on the intestinal microbiome. Male C57BL/6J mice underwent once weekly phase reversals of the light:dark cycle (i.e., circadian rhythm disrupted mice) to determine the impact of circadian rhythm disruption on the intestinal microbiome and were fed either standard chow or a high-fat, high-sugar diet to determine how diet influences circadian disruption-induced effects on the microbiome. Weekly phase reversals of the light:dark (LD) cycle did not alter the microbiome in mice fed standard chow; however, mice fed a high-fat, high-sugar diet in conjunction with phase shifts in the light:dark cycle had significantly altered microbiota. While it is yet to be established if some of the adverse effects associated with circadian disorganization in humans (e.g., shift workers, travelers moving across time zones, and in individuals with social jet lag) are mediated by dysbiosis, the current study demonstrates that circadian disorganization can impact the intestinal microbiota which may have implications for inflammatory diseases.This publication has 51 references indexed in Scilit:
- Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesityProceedings of the National Academy of Sciences of the United States of America, 2013
- Peroxiredoxins are conserved markers of circadian rhythmsNature, 2012
- The intestinal epithelial barrier in the control of homeostasis and immunityTrends in Immunology, 2011
- Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulationBrain, Behavior, and Immunity, 2011
- Search and clustering orders of magnitude faster than BLASTBioinformatics, 2010
- High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of ObesityGastroenterology, 2009
- Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitisSleep Medicine, 2009
- Tag-encoded pyrosequencing analysis of bacterial diversity in a single soil type as affected by management and land useSoil Biology and Biochemistry, 2008
- The Ribosomal Database Project: improved alignments and new tools for rRNA analysisNucleic Acids Research, 2008
- Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut MicrobiomeCell Host & Microbe, 2008