Actin' up: RhoB in cancer and apoptosis
- 1 November 2001
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Reviews Cancer
- Vol. 1 (2), 162-168
- https://doi.org/10.1038/35101096
Abstract
RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required for signalling apoptosis in transformed cells that are exposed to farnesyltransferase inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is dispensable for normal cell physiology, but that it has a suppressor or negative modifier function in stress-associated processes, including cancer.Keywords
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