Overexpression of KLF13 and FGFR3 in Oral Cancer Cells
- 1 June 2010
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 128 (4), 192-198
- https://doi.org/10.1159/000308303
Abstract
KLF13 and FGFR3 have important cellular functions and each is believed to play a role in cancer. KLF13 is a transcription factor required for the expression of several oncogenes. FGFR3 is a fibroblast growth factor receptor that initiates a signaling cascade leading to the activation of numerous cellular pathways. Here we show that KLF13 and FGFR3 are overexpressed in oral cancer cells. We also show that artificially reducing cellular levels of KLF13 and FGFR3 decreases cell proliferation and increases sensitivity to ionizing radiation. These data suggest that KLF13 and FGFR3 contribute to malignancy in oral cancer cells and may be useful biomarkers for early detection and possible targets for therapy.Keywords
This publication has 37 references indexed in Scilit:
- The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell linesOral Oncology, 2007
- FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancerThe Journal of Pathology, 2007
- Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinomaGenes, Chromosomes and Cancer, 2007
- Genes and molecular pathways related to radioresistance of oral squamous cell carcinoma cellsInternational Journal of Cancer, 2007
- The KLF Family of Transcriptional Regulators in Cardiomyocyte Proliferation and DifferentiationCell Cycle, 2007
- The Kruppel-like transcription factor KLF13 is a novel regulator of heart developmentThe EMBO Journal, 2006
- Expression of CCL5 (RANTES) and CCR5 in prostate cancerThe Prostate, 2005
- Mechanisms underlying differential responses to FGF signalingCytokine & Growth Factor Reviews, 2005
- RFLAT-1: A New Zinc Finger Transcription Factor that Activates RANTES Gene Expression in T LymphocytesImmunity, 1999
- Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines.1997