Failure of Alpha-Phenylbutyrate and Beta-Phenylvalerate in Treatment of Hypercholesterolemia
- 1 March 1957
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 15 (3), 391-396
- https://doi.org/10.1161/01.cir.15.3.391
Abstract
Sodium alpha-phenylbutyrate and sodium beta-phenyl-n-valerate have been administered to a carefully controlled group of hypercholesterolemic patients. Prior reports that these compounds are effective in the treatment of hypercholesterolemia are not confirmed. Two patients developed toxic reactions requiring cessation of treatment. The ineffectiveness of these drugs, despite their inhibitory effect on the synthesis of cholesterol from acetate, is discussed in terms of recent biochemical information concerning their site of action.This publication has 3 references indexed in Scilit:
- INHIBITORS OF CHOLESTEROL BIOSYNTHESIS AND THE PROBLEM OF HYPERCHOLESTEROLEMIAAnnals of the New York Academy of Sciences, 1956
- Inhibition of Lipid Synthesis by Alpha-Phenyl-N-Butyrate and Related CompoundsExperimental Biology and Medicine, 1955
- THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUMJCI Insight, 1955