Prognostic Effect and Longitudinal Hemodynamic Assessment of Borderline Pulmonary Hypertension
Open Access
- 1 December 2017
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Cardiology
- Vol. 2 (12), 1361-1368
- https://doi.org/10.1001/jamacardio.2017.3882
Abstract
Pulmonary hypertension (PH) is a highly morbid disease that develops from a primary pulmonary vasculopathy or secondary to chronic pulmonary, cardiac, or systemic illnesses.1-3 Pulmonary hypertension is currently defined by a mean pulmonary arterial pressure (mPAP) value of at least 25 mm Hg on right heart catheterization (RHC),1 a definition “empirically and arbitrarily” established by a consensus gathering of PH experts in 1973.4 This mPAP threshold is not based on physiologic data; in fact, the mean (SD) mPAP in healthy patients is 14.0 (3.3) mm Hg,5 suggesting an upper limit of normal significantly less than 25 mm Hg.Keywords
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