Alternatively Activated Macrophages in Spinal Cord Injury and Remission: Another Mechanism for Repair?
- 16 January 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Molecular Neurobiology
- Vol. 47 (3), 1011-1019
- https://doi.org/10.1007/s12035-013-8398-6
Abstract
Tissues within the central nervous system (CNS) have generally been regarded as immunologically privileged. However, in recent decades, it has been shown that immune reactions in the CNS continuously occur via various types of inflammation following autoimmune diseases and mechanical insults such as spinal cord injury (SCI). Among the various inflammatory cells associated with CNS disease, activated macrophages are classically known to induce detrimental consequences that are mediated by the secretion of pro-inflammatory molecules. Alternatively activated macrophages have recently been shown to modulate various types of CNS inflammation, including SCI. This review summarizes the potential roles of alternatively activated macrophages in the course of CNS inflammation in rodent SCI models.Keywords
This publication has 88 references indexed in Scilit:
- Microglial physiopathology: how to explain the dual role of microglia after acute neural disorders?Brain and Behavior, 2012
- ICV‐transplanted human glial precursor cells are short‐lived yet exert immunomodulatory effects in mice with EAEGlia, 2012
- Precursor Cell Biology and the Development of Astrocyte Transplantation Therapies: Lessons from Spinal Cord InjuryNeurotherapeutics, 2011
- Encapsulated mesenchymal stromal cells for in vivo transplantationBiotechnology & Bioengineering, 2011
- Spinal Cord Injury: A Systematic Review of Current Treatment OptionsClinical Orthopaedics and Related Research, 2011
- Neural precursors exhibit distinctly different patterns of cell migration upon transplantation during either the acute or chronic phase of EAE: A serial MR imaging studyMagnetic Resonance in Medicine, 2011
- Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical ApplicationsThe International Journal of Cell Cloning, 2011
- Functional recovery of stepping in rats after a complete neonatal spinal cord transection is not due to regrowth across the lesion siteNeuroscience, 2010
- A straight alley version of the BBB locomotor scaleExperimental Neurology, 2009
- The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injuryExperimental Neurology, 1995