Evidence for Bone Marrow Adult Stem Cell Plasticity: Properties, Molecular Mechanisms, Negative Aspects, and Clinical Applications of Hematopoietic and Mesenchymal Stem Cells Transdifferentiation
Open Access
- 1 January 2013
- journal article
- review article
- Published by Hindawi Limited in Stem Cells International
- Vol. 2013, 1-11
- https://doi.org/10.1155/2013/589139
Abstract
In contrast to the pluripotentembryonic stem cells(ESCs) which are able to give rise to all cell types of the body, mammalianadult stem cells(ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. Recently, surprising new findings have contradicted central dogmas of commitment of ASCs by showing their plasticity to differentiate across tissue lineage boundaries, irrespective of classical germ layer designations. The present paper supports the plasticity of thebone marrow stem cells(BMSCs), bringing the most striking and the latest evidences of the transdifferentiation properties of thebone marrow hematopoietic and mesenchymal stem cells(BMHSCs, and BMMSCs), the two BM populations of ASCs better characterized. In addition, we report the possible mechanisms that may explain these events, outlining the clinical importance of these phenomena and the relative problems.Keywords
Funding Information
- Associazione Italiana per la Ricerca sul Cancro (9965, 278706)
This publication has 91 references indexed in Scilit:
- Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical ApplicationsThe International Journal of Cell Cloning, 2011
- Use of Encapsulated Stem Cells to Overcome the Bottleneck of Cell Availability for Cell Therapy ApproachesTransfusion Medicine and Hemotherapy, 2010
- Adult stem cells and their trans-differentiation potential—perspectives and therapeutic applicationsJournal of Molecular Medicine, 2008
- Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cellsBMC Genomics, 2008
- MicroRNAs regulate synthesis of the neurotransmitter substance P in human mesenchymal stem cell-derived neuronal cellsProceedings of the National Academy of Sciences of the United States of America, 2007
- Stem Cells: A Revolution in Therapeutics—Recent Advances in Stem Cell Biology and Their Therapeutic Applications in Regenerative Medicine and Cancer TherapiesClinical Pharmacology & Therapeutics, 2007
- Vasculogenic mimicry by bone marrow macrophages in patients with multiple myelomaOncogene, 2007
- Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statementCytotherapy, 2006
- MicroRNAs Modulate Hematopoietic Lineage DifferentiationScience, 2004
- From Marrow to Brain: Expression of Neuronal Phenotypes in Adult MiceScience, 2000