How B cells capture, process and present antigens: a crucial role for cell polarity
- 25 June 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 13 (7), 475-486
- https://doi.org/10.1038/nri3469
Abstract
B cells are key components of the adaptive immune response. Their differentiation into either specific memory B cells or antibody-secreting plasma cells is a consequence of activation steps that involve the processing and presentation of antigens. The engagement of B cell receptors by surface-tethered antigens leads to the formation of an immunological synapse that coordinates cell signalling events and that promotes antigen uptake for presentation on MHC class II molecules. In this Review, we discuss membrane trafficking and the associated molecular mechanisms that are involved in antigen extraction and processing at the B cell synapse, and we highlight how B cells use cell polarity to coordinate the complex events that ultimately lead to efficient humoral responses.Keywords
This publication has 117 references indexed in Scilit:
- Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil MigrationCell, 2012
- Polarized Secretion of Lysosomes at the B Cell Synapse Couples Antigen Extraction to Processing and PresentationImmunity, 2011
- Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiationCurrent Opinion in Immunology, 2011
- Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent ReporterCell, 2010
- Modeling of B cell Synapse Formation by Monte Carlo Simulation Shows That Directed Transport of Receptor Molecules Is a Potential Formation MechanismCellular and Molecular Bioengineering, 2010
- The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell ReceptorImmunity, 2010
- Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody productionNature Immunology, 2009
- Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cellsNature, 2007
- Germinal-Center Organization and Cellular DynamicsImmunity, 2007
- Balanced responsiveness to chemoattractants from adjacent zones determines B-cell positionNature, 2002