Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture
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- 17 July 2005
- journal article
- letter
- Published by Springer Science and Business Media LLC in Nature Materials
- Vol. 4 (8), 612-616
- https://doi.org/10.1038/nmat1428
Abstract
Properties of the organic matrix of bone1 as well as its function in the microstructure2 could be the key to the remarkable mechanical properties of bone3. Previously, it was found that on the molecular level, calcium-mediated sacrificial bonds increased stiffness and enhanced energy dissipation in bone constituent molecules4,5. Here we present evidence for how this sacrificial bond and hidden length mechanism contributes to the mechanical properties of the bone composite, by investigating the nanoscale arrangement of the bone constituents6,7,8 and their interactions. We find evidence that bone consists of mineralized collagen fibrils and a non-fibrillar organic matrix2, which acts as a ‘glue’ that holds the mineralized fibrils together. We believe that this glue may resist the separation of mineralized collagen fibrils. As in the case of the sacrificial bonds in single molecules5, the effectiveness of this mechanism increases with the presence of Ca2+ ions.Keywords
This publication has 28 references indexed in Scilit:
- Effect of aging on the toughness of human cortical bone: evaluation by R-curvesBone, 2004
- Bone recognition mechanism of porcine osteocalcin from crystal structureNature, 2003
- Probing Solid Surfaces with Single PolymersChemphyschem, 2003
- Molecular nanosprings in spider capture-silk threadsNature Materials, 2003
- Mechanistic fracture criteria for the failure of human cortical boneNature Materials, 2003
- Does microdamage accumulation affect the mechanical properties of bone?Journal of Biomechanics, 1998
- Scanning electron microscopy of human cortical bone failure surfacesJournal of Biomechanics, 1997
- The distribution of soluble, mineral-bound, and matrix-bound proteins in osteoporotic and normal bonesBone, 1994
- Journal of Bone and Mineral ResearchJournal of Bone and Mineral Research, 1993
- Evaluation of orthogonal mechanical properties and density of human trabecular bone from the major metaphyseal regions with materials testing and computed tomographyJournal of Orthopaedic Research, 1991