Distinct functional networks associated with improvement of affective symptoms and cognitive function during citalopram treatment in geriatric depression
Open Access
- 30 September 2010
- journal article
- research article
- Published by Wiley in Human Brain Mapping
- Vol. 32 (10), 1677-1691
- https://doi.org/10.1002/hbm.21135
Abstract
Variability in the affective and cognitive symptom response to antidepressant treatment has been observed in geriatric depression. The underlying neural circuitry is poorly understood. This study evaluated the cerebral glucose metabolic effects of citalopram treatment and applied multivariate, functional connectivity analyses to identify brain networks associated with improvements in affective symptoms and cognitive function. Sixteen geriatric depressed patients underwent resting positron emission tomography (PET) studies of cerebral glucose metabolism and assessment of affective symptoms and cognitive function before and after 8 weeks of selective serotonin reuptake inhibitor treatment (citalopram). Voxel‐wise analyses of the normalized glucose metabolic data showed decreased cerebral metabolism during citalopram treatment in the anterior cingulate gyrus, middle temporal gyrus, precuneus, amygdala, and parahippocampal gyrus. Increased metabolism was observed in the putamen, occipital cortex, and cerebellum. Functional connectivity analyses revealed two networks which were uniquely associated with improvement of affective symptoms and cognitive function during treatment. A subcortical‐limbic‐frontal network was associated with improvement in affect (depression and anxiety), while a medial temporal‐parietal‐frontal network was associated with improvement in cognition (immediate verbal learning/memory and verbal fluency). The regions that comprise the cognitive network overlap with the regions that are affected in Alzheimer's dementia. Thus, alterations in specific brain networks associated with improvement of affective symptoms and cognitive function are observed during citalopram treatment in geriatric depression. Hum Brain Mapp, 2010.Keywords
Funding Information
- National Institute of Health (MH 01621, MH 49936, MH 57078, MH 64823, M01 RR 018535)
This publication has 75 references indexed in Scilit:
- Serotonin Modulation of Cerebral Glucose Metabolism in Depressed Older AdultsBiological Psychiatry, 2009
- The functional neuroanatomy of geriatric depressionInternational Journal of Geriatric Psychiatry, 2009
- Serotonin transporter occupancy by citalopram treatment in geriatric depressionNeuroImage, 2008
- Depression and Risk for Alzheimer DiseaseArchives of General Psychiatry, 2006
- Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and MemoryJournal of Neuroscience, 2005
- Partial least squares analysis of neuroimaging data: applications and advancesNeuroImage, 2004
- Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjectsSynapse, 2002
- Hippocampal and Anterior Cingulate Activation Deficits in Patients With Geriatric DepressionAmerican Journal of Psychiatry, 2001
- Parahippocampal Activation during Successful Recognition of Words: A Self-Paced Event-Related fMRI StudyNeuroImage, 2001
- A RATING SCALE FOR DEPRESSIONJournal of Neurology, Neurosurgery & Psychiatry, 1960