VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer
Open Access
- 22 November 2010
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 207 (13), 2855-2868
- https://doi.org/10.1084/jem.20100438
Abstract
Inflammation drives expression of VEGFR2, which is expressed on and drives growth of tumor cells in colitis-associated cancer.Keywords
This publication has 53 references indexed in Scilit:
- STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healingThe Journal of Experimental Medicine, 2009
- Transgenic Expression of VEGF in Intestinal Epithelium Drives Mesenchymal Cell Interactions and Epithelial NeoplasiaGastroenterology, 2009
- IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated CancerCancer Cell, 2009
- The transcription factor IFN regulatory factor–4 controls experimental colitis in mice via T cell–derived IL-6JCI Insight, 2008
- Integrins in angiogenesis and lymphangiogenesisNature Reviews Cancer, 2008
- Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitisJCI Insight, 2008
- Proinflammatory Role of Vascular Endothelial Growth Factor in the Pathogenesis of Rheumatoid Arthritis: Prospects for Therapeutic InterventionMediators of Inflammation, 2008
- Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: The role for KDR and MMP-9Biochemical and Biophysical Research Communications, 2006
- Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesisExperimental Cell Research, 2005
- Tumor Angiogenesis: Therapeutic ImplicationsNew England Journal of Medicine, 1971