Laminin 332 in squamous-cell carcinoma
- 1 May 2007
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Cancer
- Vol. 7 (5), 370-380
- https://doi.org/10.1038/nrc2089
Abstract
Basement membranes can be a barrier to tumour growth, but basement membrane molecules, including laminins, are also important autocrine factors produced by cancers to promote tumorigenesis. Many studies have shown the importance of laminin 332 (previously known as laminin 5) in this process, especially in squamous cell carcinoma. Through interactions with several cell-surface receptors (including alpha6beta4 and alpha3beta1 integrins, epidermal growth factor receptor and syndecan 1) and other basement membrane components (including type VII collagen), laminin 332 drives tumorigenesis through phosphatidylinositol-3 kinase (PI3K) and RAC1 activation, promoting tumour invasion and cell survival. The extracellular interactions of laminin 332 appear amenable to antibody-mediated therapies.Keywords
This publication has 91 references indexed in Scilit:
- Integrin signalling during tumour progressionNature Reviews Molecular Cell Biology, 2004
- Syndecans in tumor cell adhesion and signalingReproductive Biology and Endocrinology, 2004
- Proteolyzed matrix as a template for the regulation of tumor progressionBiomedicine & Pharmacotherapy, 2003
- Clinical, Cellular, and Molecular Aspects of Cancer InvasionPhysiological Reviews, 2003
- Laminins and human diseaseMicroscopy Research and Technique, 2000
- Immunodissection of the connective tissue matrix in human skinMicroscopy Research and Technique, 1997
- Nonmelanoma skin cancer in the United States: IncidenceJournal of the American Academy of Dermatology, 1994
- Metastases from Squamous Cell Carcinoma of the Skin in Southern AustraliaDermatology, 1994
- BIOCHEMICAL INTERACTIONS OF TUMOR CELLS WITH THE BASEMENT MEMBRANEAnnual Review of Biochemistry, 1986
- Metastatic potential correlates with enzymatic degradation of basement membrane collagenNature, 1980