Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis
Open Access
- 1 July 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 26 (9), 2442-2451
- https://doi.org/10.1093/humrep/der197
Abstract
Our aim was to assess differences in anxiety and depression between women with and without (controls) polycystic ovary syndrome (PCOS). We conducted a systematic review and meta-analysis of published literature comparing women with PCOS to control groups on anxiety and depression. Electronic databases were searched up to 17 December 2010. The inverse variance method based, as appropriate, on a random- or fixed-effects model in Review Manager, Version 5 was used to analyse the data. Twelve comparative studies were included; all studies assessed depression (910 women with PCOS and 1347 controls) and six also assessed anxiety (208 women with PCOS and 169 controls). Analysis revealed higher depression (Z = 17.92, P < 0.00001; Hedges’ g = 0.82; 95% CI 0.73–0.92) and anxiety (Z = 5.03, P < 0.00001; Hedges’ g = 0.54; 95% CI 0.33–0.75) scores in the participants with, than without, PCOS. Studies controlling for BMI showed a smaller difference between women with PCOS and controls on anxiety and depression scores than studies not controlling for BMI. Women with PCOS on average tend to experience mildly elevated anxiety and depression, significantly more than women without PCOS. Women with PCOS with lower BMI tended to have slightly lower anxiety and depression scores, suggesting that having a lower BMI reduces anxiety and depression. Future studies might consider (i) controlling for BMI, (ii) stratifying by medication use in order to control for any anti-androgenic effects of medication and (iii) excluding women with polycystic ovaries from control groups.Keywords
This publication has 35 references indexed in Scilit:
- Testosterone and mood dysfunction in women with polycystic ovarian syndrome compared to subfertile controlsJournal of Psychosomatic Obstetrics & Gynecology, 2011
- Insulin resistance, obesity, inflammation, and depression in polycystic ovary syndrome: biobehavioral mechanisms and interventionsFertility and Sterility, 2010
- Disturbed stress responses in women with polycystic ovary syndromePsychoneuroendocrinology, 2009
- The Relationship between Clinico-Biochemical Characteristics and Psychiatric Distress in Young Women with Polycystic Ovary SyndromeJournal of International Medical Research, 2008
- Obesity, depression, and chronic low-grade inflammation in women with polycystic ovary syndromeBrain, Behavior, and Immunity, 2008
- Quality of life and psychological well being in polycystic ovary syndromeHuman Reproduction, 2007
- Androgen production in womenFertility and Sterility, 2002
- Polycystic Ovary SyndromeThe New England Journal of Medicine, 1995
- Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluationClinical Psychology Review, 1988
- An Inventory for Measuring DepressionArchives of General Psychiatry, 1961