Carbohydrates as Scaffolds in Drug Discovery
- 31 October 2006
- journal article
- review article
- Published by Wiley in ChemMedChem
- Vol. 1 (11), 1164-1194
- https://doi.org/10.1002/cmdc.200600150
Abstract
Drug discovery has long suffered from the difficulty of having to place pharmacophoric groups in just the right spatial arrangement to elicit the desired biological response. Although some molecule classes have been discovered that seem to be privileged structures for at least some drug–receptor interactions, there remains the challenge to design and synthesize molecules with high specific affinity to pharmacologically important targets. With their high density of stereochemical information and their relative rigidity, carbohydrates provide excellent platforms upon which to display a number of substituents in a sterically defined way, hence offering the opportunity to harness their unique features for the drug‐discovery process. This review highlights the progress that has been made in the development of carbohydrate scaffolds for drug discovery.Keywords
This publication has 75 references indexed in Scilit:
- Regioselective Conversion of the Secondary Hydroxyl Groups ofD-Glucuronic Acid without the Requirement ofO-Protecting GroupsChemistry – A European Journal, 2005
- Identifying Specific Conformations by Using a Carbohydrate Scaffold: Discovery of Subtype‐Selective LPA‐Receptor Agonists and an AntagonistAngewandte Chemie, 2004
- An vier Positionen in beliebiger Reihenfolge selektiv deblockierbare Kohlenhydratgerüste für die kombinatorische SyntheseAngewandte Chemie, 2004
- Structure–activity relationships of azasugar-based MMP/ADAM inhibitorsBioorganic & Medicinal Chemistry Letters, 2003
- Effects of Heterocyclic Aromatic Substituents on Binding Affinities at Two Distinct Sites of Somatostatin Receptors. Correlation with the Electrostatic Potential of the SubstituentsJournal of Medicinal Chemistry, 2003
- Carbohydrate-Based Scaffolds for the Generation of Sortiments of Bioactive CompoundsMonatshefte für Chemie / Chemical Monthly, 2002
- Glycosaminosäuren und ihre Verwendung als Bausteine in der kombinatorischen Synthese sowie ihre Bedeutung für die Wirkstoff-ForschungAngewandte Chemie, 2002
- Design, Synthesis, and Biological Evaluation ofα4β1 Integrin Antagonists Based onβ-D-Mannose as Rigid ScaffoldAngewandte Chemie-International Edition, 2001
- Discovery of Novel Disaccharide Antibacterial Agents Using a Combinatorial Library ApproachJournal of Medicinal Chemistry, 1999
- Design, synthesis, and binding affinity of a nonpeptide mimic of somatostatinBioorganic & Medicinal Chemistry Letters, 1992