Real-Time, Label-Free Detection of Biological Entities Using Nanowire-Based FETs
- 26 September 2008
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Nanotechnology
- Vol. 7 (6), 651-667
- https://doi.org/10.1109/tnano.2008.2006165
Abstract
Nanowire (NW)-based FETs are promising devices with potential applications ranging from health monitoring to drug discovery. In fact, these devices have demonstrated the ability to detect a variety of analytes such as particular DNA sequences, cancer biomarkers, and larger entities such as viruses. These sensor devices have also been used to monitor enzymatic activities and study the behavior of potential drug molecules. The detection of the analytes occurs with high specificity and sensitivity in reasonably short time. Here, we review the recent literature produced in the field of NW FET biosensors. We elaborate on the parameters that ultimately influence device performance such as methods of NW production, device dimensionality, and active measurement conditions. Significant progress has been made in this field of technology; however, it is often difficult to compare literature reports due to differences in both measurement conditions and data analysis. The standardization of certain active measurement conditions, such as the ionic strength of the analyte solutions, and manipulation of data are proposed to facilitate comparison between different NW biosensors.Keywords
This publication has 71 references indexed in Scilit:
- Importance of the Debye Screening Length on Nanowire Field Effect Transistor SensorsNano Letters, 2007
- Carbon Nanotubes for Electronic and Electrochemical Detection of BiomoleculesAdvanced Materials, 2007
- Label-free immunodetection with CMOS-compatible semiconducting nanowiresNature, 2007
- Carbon nanotubes as nanomedicines: From toxicology to pharmacology☆Advanced Drug Delivery Reviews, 2006
- Quantitative Real-Time Measurements of DNA Hybridization with Alkylated Nonoxidized Silicon Nanowires in Electrolyte SolutionJournal of the American Chemical Society, 2006
- Label‐free detection of DNA using field‐effect transistorsPhysica Status Solidi (a), 2006
- Silicon-on-insulator based thin film resistors for quantitative biosensing applicationsPhysica Status Solidi (a), 2006
- Performance limits of nanobiosensorsApplied Physics Letters, 2006
- Covalent functionalization and biomolecular recognition properties of DNA-modified silicon nanowiresNanotechnology, 2005
- Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical SpeciesScience, 2001