Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: an immunofluorescence study
- 3 February 2011
- journal article
- Published by Springer Science and Business Media LLC in Neurological Sciences
- Vol. 32 (2), 361-363
- https://doi.org/10.1007/s10072-010-0475-2
Abstract
Bortezomib is a new chemotherapeutic agent approved for the treatment of relapsed/refractory and newly diagnosed multiple myeloma. One of the major side effects of bortezomib is a peripheral length-dependent sensory axonal neuropathy and, less frequently, a small fiber neuropathy. Autonomic symptoms like postural dizziness, syncope, diarrhoea, ileus, impotence and urinary disturbances have been reported, nevertheless, autonomic neuropathy has never been characterized. We describe by means of immunofluorescence, the involvement of autonomic skin nerve fibers in three patients with small fiber neuropathy induced by bortezomib treatment.Keywords
This publication has 10 references indexed in Scilit:
- Autonomic innervation in multiple system atrophy and pure autonomic failureJournal of Neurology, Neurosurgery & Psychiatry, 2010
- Bortezomib‐induced painful neuropathy in rats: A behavioral, neurophysiological and pathological study in ratsEuropean journal of pain, 2010
- Single-Agent Bortezomib in Previously Untreated Multiple Myeloma: Efficacy, Characterization of Peripheral Neuropathy, and Molecular Correlations With Response and NeuropathyJournal of Clinical Oncology, 2009
- Bortezomib-induced peripheral neuropathy in multiple myeloma: a comprehensive review of the literatureBlood, 2008
- Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitorEuropean Journal of Gastroenterology & Hepatology, 2007
- Quantitative Sensory Findings in Patients With Bortezomib-Induced PainThe Journal of Pain, 2007
- Experimental Neurology, 2007
- Life-threatening motor neurotoxicity in association with bortezomib.2006
- Clinical and experimental findings in humans and animals with chemotherapy-induced peripheral neuropathy.2006
- Bortezomib (Velcade?) in the treatment of multiple myelomaTherapeutics and Clinical Risk Management, 2006