Comparison of Human and Animal Surveillance Data for H5N1 Influenza A in Egypt 2006–2011
Open Access
- 27 September 2012
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 7 (9), e43851
- https://doi.org/10.1371/journal.pone.0043851
Abstract
The majority of emerging infectious diseases are zoonotic (transmissible between animals and humans) in origin, and therefore integrated surveillance of disease events in humans and animals has been recommended to support effective global response to disease emergence. While in the past decade there has been extensive global surveillance for highly pathogenic avian influenza (HPAI) infection in both animals and humans, there have been few attempts to compare these data streams and evaluate the utility of such integration. We compared reports of bird outbreaks of HPAI H5N1 in Egypt for 2006–2011 compiled by the World Organisation for Animal Health (OIE) and the UN Food and Agriculture Organization (FAO) EMPRESi reporting system with confirmed human H5N1 cases reported to the World Health Organization (WHO) for Egypt during the same time period. Both human cases and bird outbreaks showed a cyclic pattern for the country as a whole, and there was a statistically significant temporal correlation between the data streams. At the governorate level, the first outbreak in birds in a season usually but not always preceded the first human case, and the time lag between events varied widely, suggesting regional differences in zoonotic risk and/or surveillance effectiveness. In a multivariate risk model, lower temperature, lower urbanization, higher poultry density, and the recent occurrence of a bird outbreak were associated with increased risk of a human case of HPAI in the same governorate, although the positive predictive value of a bird outbreak was low. Integrating data streams of surveillance for human and animal cases of zoonotic disease holds promise for better prediction of disease risk and identification of environmental and regional factors that can affect risk. Such efforts can also point out gaps in human and animal surveillance systems and generate hypotheses regarding disease transmission.This publication has 14 references indexed in Scilit:
- The Epidemiological and Molecular Aspects of Influenza H5N1 Viruses at the Human-Animal Interface in EgyptPLOS ONE, 2011
- Seroprevalence of Antibodies to Avian Influenza Virus A (H5N1) among Residents of Villages with Human Cases, Thailand, 20051Emerging Infectious Diseases, 2009
- Molecular epidemiology of H5N1 avian influenza.Revue Scientifique et Technique de l'OIE, 2009
- Highly Pathogenic Avian Influenza Virus Subtype H5N1 in Africa: A Comprehensive Phylogenetic Analysis and Molecular Characterization of IsolatesPLOS ONE, 2009
- Epidemiological Findings of Outbreaks of Disease Caused by Highly Pathogenic H5N1 Avian Influenza Virus in Poultry in Egypt During 2006Avian Diseases, 2008
- From “Us vs. Them” to “Shared Risk”: Can Animals Help Link Environmental Factors to Human Health?Ecohealth, 2008
- Dynamic patterns of avian and human influenza in east and southeast AsiaThe Lancet Infectious Diseases, 2007
- Possible Avian Influenza (H5N1) from Migratory Bird, EgyptEmerging Infectious Diseases, 2007
- Predicting the global spread of H5N1 avian influenzaProceedings of the National Academy of Sciences of the United States of America, 2006
- Host Range and Emerging and Reemerging PathogensEmerging Infectious Diseases, 2005