The Effects of Heliox on the Output and Particle-Size Distribution of Salbutamol Using Jet and Vibrating Mesh Nebulizers
- 1 December 2007
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Aerosol Medicine
- Vol. 20 (4), 434-444
- https://doi.org/10.1089/jam.2007.0614
Abstract
There are theoretical benefits of delivering drug aerosols to patients with asthma and chronic obstructive pulmonary disease (COPD) using Heliox as a carrier gas. The objective of this study was to develop systems to allow bronchodilators nebulized by a breath enhanced jet nebulizer and a vibrating mesh nebulizer to be delivered to patients in Heliox. This was achieved by attaching a reservoir to the nebulizers to ensure inhaled Heliox was not diluted by entrained air. For the vibrating mesh nebulizer, the total output was significantly higher after 5 min of nebulization when Heliox rather than air was used as the delivery gas (p < 0.001). The proportion of drug in particles <5 microm was 58.1% for Heliox and 50.1% when air was entrained. When the breath enhanced nebulizer was used a much higher driving flow of Heliox, compared to air, was required to deliver a similar dose of drug (p < 0.05). The total amount of drug likely to be inhaled was significantly higher when the vibrating mesh nebulizer (Aerogen) was used compared to the breath enhanced jet nebulizer (Pari LC plus) (p < 0.001). The amount of drug likely to be inhaled was also significantly greater for the adult as opposed to pediatric breathing pattern for all nebulizers and flows tested with the exception of the Aeroneb and Heliox entrainment. In this case, total amounts were similar for both patterns but for the pediatric pattern, the time taken to reach this output was longer. Such information is required to allow appropriate interpretation of clinical trials of drug delivery using Heliox.1541Keywords
This publication has 20 references indexed in Scilit:
- Helium/Oxygen-Driven Albuterol Nebulization in the Treatment of Children With Moderate to Severe Asthma Exacerbations: A Randomized, Controlled TrialPEDIATRICS, 2005
- Development of Aerosol Drug Delivery with Helium Oxygen Gas MixturesJournal of Aerosol Medicine, 2004
- Heliox vs Air-Oxygen Mixtures for the Treatment of Patients With Acute AsthmaaSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2003
- Ventilatory response to exercise in aged runners breathing He-O2 or inspired CO2Journal of Applied Physiology, 2003
- The Utility of Albuterol Nebulized with Heliox during Acute Asthma ExacerbationsAmerican Journal of Respiratory and Critical Care Medicine, 2002
- The Effect of Heliox-Driven Bronchodilator Aerosol Therapy on Pulmonary Function Tests in Patients with AsthmaJournal of Asthma, 2002
- Randomized trial of the use of heliox as a driving gas for updraft nebulization of bronchodilators in the emergent treatment of acute exacerbations of chronic obstructive pulmonary diseaseCritical Care Medicine, 2000
- The Effect of Heliox on Nebulizer Function Using a β-Agonist BronchodilatorSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1999
- The Effects of Breathing He–O2 Mixtures on Maximal Oxygen Consumption in Normoxic and Hypoxic MenJournal Of Physiology-London, 1997
- Dilution of nebulised aerosols by air entrainment in childrenThe Lancet, 1990