In vitro effect of karathane LC (dinocap) on human lymphocytes
Open Access
- 1 March 2005
- journal article
- Published by Oxford University Press (OUP) in Mutagenesis
- Vol. 20 (2), 101-104
- https://doi.org/10.1093/mutage/gei013
Abstract
Karathane LC (active ingredient dinocap), a contact fungicide and a non-systemic acaricide was investigated for its ability to induce chromosome aberrations (CAs) and sister chromatid exchanges (SCEs) in cultured human lymphocytes of peripheral blood. In addition to the cytogenetic analysis, the effect of karathane LC on the cell proliferation kinetics (CPK) by the replication index (RI) was studied. The mitotic index (MI) was also determined to detect the cytotoxic effect. Lymphocytes were treated with four different concentrations (5, 10, 15 and 20 µg/ml) of karathane LC for 24 and 48 h. Significant differences between exposed and non-exposed groups found in CAs, SCEs and MI demonstrate the mutagenic, clastogenic and also the cytotoxic effect of karathane LC.Keywords
This publication has 33 references indexed in Scilit:
- Pancreatic cancer mortality and organochlorine pesticide exposure in California, 1989–1996American Journal of Industrial Medicine, 2003
- Organophosphate-based pesticides and genetic damage implicated in bladder cancerCancer Genetics and Cytogenetics, 2002
- Chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with sodium metabisulfite, a food preservativeMutation Research - Genetic Toxicology and Environmental Mutagenesis, 2001
- Chromosomal Aberrations in Cultured Human Lymphocytes Treated with the Mixtures of Carbosulfan, Ethyl Carbamate and Ethyl Methanesulfonate.CYTOLOGIA, 2000
- Geographical differences of cancer incidence in Costa Rica in relation to environmental and occupational pesticide exposureInternational Journal of Epidemiology, 1999
- Lack of genotoxicity of the herbicide atrazine in cultured human lymphocytesMutation Research - Genetic Toxicology and Environmental Mutagenesis, 1998
- Meta-analyses of multiple myeloma and farmingAmerican Journal of Industrial Medicine, 1997
- Genotoxicity of the herbicide butachlor in cultured human lymphocytesMutation Research/Genetic Toxicology, 1995
- Cancer among farmers in central Italy.Scandinavian Journal of Work, Environment & Health, 1993
- Chromosomal aberrations in cultured human lymphocytes treated with Marshal and its effective ingredient CarbosulfanMutation Research/Genetic Toxicology, 1993