Whole-body distribution and dosimetry of O-(2-[18F]fluoroethyl)-l-tyrosine
- 15 February 2003
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Nuclear Medicine and Molecular Imaging
- Vol. 30 (4), 519-524
- https://doi.org/10.1007/s00259-003-1118-0
Abstract
The whole-body distribution of O-(2-[(18)F]fluoroethyl)- l-tyrosine (FET) was studied in seven patients with brain tumours by positron emission tomography (PET). Based on the IMEDOSE and MIRDOSE procedures, radiation absorbed doses were estimated from whole-body PET scans acquired approximately 70 and 200 min after i.v. injection of 400 MBq FET. After injection of FET, the peak of radioactivity in the blood was observed after 1.5 min, and a plateau of nearly constant radioactivity was reached at 20 min. The whole-body distribution of FET showed the highest activities in the urinary tract. All other organs exhibited only moderate FET uptake (SUV </=1.6) which remained constant between early and late PET scans. No increased uptake was seen in the bone, the biliary tract or the pancreas. Twenty-two percent of the injected activity was excreted 5 h p.i. (approx. 5.3% ID/h). The highest absorbed dose was found for the urinary bladder wall. The effective dose according to ICRP 60 was 16.5 micro Sv/MBq for adults, which would lead to an effective dose of 6.1 mSv in a PET study using 370 MBq FET.Keywords
This publication has 21 references indexed in Scilit:
- Efficient routine production of the 18F-labelled amino acid O-(2-[18F]fluoroethyl)-l-tyrosineApplied Radiation and Isotopes, 2002
- 3-[123I]Iodo-α-methyl-L-tyrosine: uptake mechanisms and clinical applicationsNuclear Medicine and Biology, 2002
- Multimodal target point assessment for stereotactic biopsy in children with diffuse bithalamic astrocytomasChild's Nervous System, 2002
- O-(2-[18F]Fluoroethyl)-L-tyrosine (FET): a tracer for differentiation of tumour from inflammation in murine lymph nodesEuropean Journal of Nuclear Medicine and Molecular Imaging, 2002
- 18F-FDG and 18F-FET uptake in experimental soft tissue infectionEuropean Journal of Nuclear Medicine and Molecular Imaging, 2002
- Fluorinated amino acids for tumour imaging with positron emission tomographyEuropean Journal of Nuclear Medicine and Molecular Imaging, 2002
- Comparison of 3-D reconstruction with 3D-OSEM and with FORE+OSEM for PETIEEE Transactions on Medical Imaging, 2001
- Whole-body kinetics and dosimetry ofl-3-[123I]iodo-?-methyltyrosineEuropean Journal of Nuclear Medicine and Molecular Imaging, 1997
- Biochemistry and Evaluation of Fluoroamino AcidsPublished by Springer Science and Business Media LLC ,1993
- Dose to the Fetus from Radionuclides in the BladderHealth Physics, 1973