Chemoprevention of lung cancers: lessons from CARET, the beta-carotene and retinol efficacy trial, and prospects for the future
- 1 June 2007
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in European Journal of Cancer Prevention
- Vol. 16 (3), 184-191
- https://doi.org/10.1097/01.cej.0000215612.98132.18
Abstract
The objective of this paper was to review the strategies for lung cancer chemoprevention. A retrospective assessment of the major findings from the most informative lung cancer chemoprevention clinical trials [alpha-tocopherol (vitamin E), beta-carotene trial and β-carotene and retinol efficacy trial] was employed. Both trials and many others showed no benefit from what was once the prime candidate for lung cancer chemoprevention, β-carotene. Furthermore, both trials found that β-carotene, alone or in combination with vitamin E or retinyl palmitate, increased the incidence of lung cancers and the total and cardiovascular mortality rates. In conclusion, design, conduct, documentation, relationships with participants, and preparedness for unexpected findings are all important for chemoprevention research. Trials are necessary to test inferences from observational epidemiology and animal models. Multiple classes of promising agents are available for evaluation and for eventual randomized trials.Keywords
This publication has 26 references indexed in Scilit:
- Lung cancer: genetics of risk and advances in chemopreventionCurrent Opinion in Pulmonary Medicine, 2005
- Advances in the Biology of Lung Cancer ChemopreventionJournal of Clinical Oncology, 2005
- A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer PatientsJNCI Journal of the National Cancer Institute, 2005
- The Beta-Carotene and Retinol Efficacy Trial: Incidence of Lung Cancer and Cardiovascular Disease Mortality During 6-Year Follow-up After Stopping -Carotene and Retinol SupplementsJNCI Journal of the National Cancer Institute, 2004
- Cancer Statistics, 2004CA: A Cancer Journal for Clinicians, 2004
- A comparison of population-based cancer incidence rates in Israel and JordanEuropean Journal of Cancer Prevention, 2003
- Stopping the active intervention:: CARETControlled Clinical Trials, 2003
- Gene-expression profiles predict survival of patients with lung adenocarcinomaNature Medicine, 2002
- Lack of Effect of a High-Fiber Cereal Supplement on the Recurrence of Colorectal AdenomasThe New England Journal of Medicine, 2000
- The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male SmokersThe New England Journal of Medicine, 1994