Nonpalpable Breast Cancer: Mammographic Appearance as Predictor of Histologic Type
- 1 January 2002
- journal article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 222 (1), 165-170
- https://doi.org/10.1148/radiol.2221001471
Abstract
To investigate the association between mammographic appearance and histologic diagnosis of nonpalpable breast cancers. Mammographic characteristics of 317 consecutive clinically nonpalpable breast cancers in patients treated with breast-conserving surgery were reviewed. Malignant lesions were categorized as spiculated masses, other lesions, calcifications, and combined findings. Calcifications were characterized as amorphous, pleomorphic, or fine linear and branching. Logistic regression was used for the evaluation. Odds ratios (ORs) represent the magnitude of the association between a histologic diagnosis and a mammographic finding. Spiculated mass without calcifications (n = 150) and calcifications alone (n = 79) accounted for three of four cancers. A spiculated mass without calcifications was strongly associated with invasive cancers (OR = 12). Calcifications alone were strongly associated with ductal carcinoma in situ (DCIS) (OR = 19). In a decreasing order, the following invasive cancers were each associated with spiculated lesions without calcifications: ductal carcinoma grade 1 (OR = 28), ductal carcinoma grade 2 (OR = 17), lobular carcinoma (OR = 11), and ductal carcinoma grade 3 (OR = 4.6). Fine linear and branching calcifications alone were associated with not only DCIS nuclear grades 3 (OR = 17) and 2 (OR = 9.7) but also with invasive ductal carcinoma grade 3 (OR = 13). Mammographic appearance can be a predictor of histologic diagnosis in three of four nonpalpable breast cancers.Keywords
This publication has 18 references indexed in Scilit:
- A New Era in the Diagnosis of Breast CancerSurgical Oncology Clinics of North America, 2000
- Ductal carcinoma in situ of the breast: mammographic-pathologic correlation.American Journal of Roentgenology, 1998
- Microcalcifications in ductal carcinoma in situ of the breast: Histochemical and immunohistochemical studyHuman Pathology, 1996
- Non-palpable lesions of the breast detected by mammography — Review of 1182 consecutive histologically confirmed casesEuropean Journal of Cancer, 1994
- Population-based mammography screening in Swedish clinical practice: prevalence and incidence screening in Uppsala County.Radiology, 1994
- Wire localized biopsy of breast lesions: A review of 425 cases found in screening or clinical mammographyClinical Radiology, 1993
- pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐upHistopathology, 1991
- Not All Nonpalpable Breast Cancers Are AlikeArchives of Surgery, 1991
- Biopsy of Occult Breast LesionsJAMA, 1990
- Infiltrating lobular carcinoma: mammographic patterns with pathologic correlationAmerican Journal of Roentgenology, 1989