Twofold C−H Functionalization: Palladium-Catalyzed Ortho Arylation of Anilides
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- 9 May 2008
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 10 (11), 2207-2210
- https://doi.org/10.1021/ol800619c
Abstract
The ortho arylation of anilides to form biphenyls via a twofold C−H functionalization/C−C bond-forming process is described. The oxidative coupling takes place in the presence of 5−10 mol % of Pd(OAc)2, 10−20 mol % of DMSO, and 4−11 equiv of the aryl substrate in TFA under an oxygen atmosphere. No metal-containing cocatalyst is required.Keywords
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