Mechanism of V(D)J recombination
- 30 April 1996
- journal article
- review article
- Published by Elsevier BV in Current Opinion in Immunology
- Vol. 8 (2), 175-180
- https://doi.org/10.1016/s0952-7915(96)80055-0
Abstract
V(D)J recombination can be seperated into two basic operations: DNA cleavage and joining of broken ends. Our understanding of both reactions has increased substantially in the past year. Major advances include the development of a cell-free system capable of cleavage and the identification of several proteins involved in both V(D)J recombination and double-strand break repair.Keywords
This publication has 47 references indexed in Scilit:
- RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.Genes & Development, 1995
- The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative AnalysesAdvances in Immunology, 1994
- Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated.Genes & Development, 1993
- Characterization of broken DNA molecules associated with V(D)J recombination.Proceedings of the National Academy of Sciences of the United States of America, 1993
- V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair.Molecular and Cellular Biology, 1993
- V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytesCell, 1992
- V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signalsCell, 1992
- A link between double-strand break-related repair and V(D)J recombination: the scid mutation.Proceedings of the National Academy of Sciences of the United States of America, 1991
- scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.Proceedings of the National Academy of Sciences of the United States of America, 1991
- The scid mutation in mice causes a general defect in DNA repairNature, 1990