Homeotic Transformation of Rhombomere Identity After Localized Hoxb1 Misexpression
- 25 June 1999
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 284 (5423), 2168-2171
- https://doi.org/10.1126/science.284.5423.2168
Abstract
Segmentation of the hindbrain and branchial region is a conserved feature of head development, involving the nested expression of Hox genes. Although it is presumed that vertebrate Hox genes function as segment identifiers, responsible for mediating registration between elements of diverse embryonic origin, this assumption has remained untested. To assess this, retroviral misexpression was combined with orthotopic grafting in chick embryos to generate a mismatch in Hox coding between a specific rhombomere and its corresponding branchial arch. Rhombomere-restricted misexpression of a single gene, Hoxb1 , resulted in the homeotic transformation of the rhombomere, revealed by reorganization of motor axon projections.Keywords
This publication has 13 references indexed in Scilit:
- Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1Nature, 1996
- Patterning the Vertebrate NeuraxisScience, 1996
- Expression of a Delta homologue in prospective neurons in the chickNature, 1995
- Exogenous retinoic acid causes specific alterations in the development of the midbrain and hindbrain of the zebrafish embryo including positional respecification of the Mauthner neuronMechanisms of Development, 1995
- Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crestCell, 1993
- Rhombomere-specific origin of the contralateral vestibulo-acoustic efferent neurons and their migration across the embryonic midlineNeuron, 1993
- Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identityNature, 1992
- Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6Nature, 1992
- A distinct Hox code for the branchial region of the vertebrate headNature, 1991
- Segmental patterns of neuronal development in the chick hindbrainNature, 1989