Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine
- 2 June 2008
- journal article
- review article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 115 (1), 13-23
- https://doi.org/10.1042/cs20070226
Abstract
Over the last few years, it has become obvious that obesity and insulin resistance are linked by a variety of proteins secreted by adipocytes. Visfatin/PBEF (pre-B-cell colony-enhancing factor) has recently been identified as a novel adipokine with insulin-mimetic effects. Furthermore, an enzymatic function has been reported that reveals visfatin/PBEF as Nampt (nicotinamide phosphoribosyltransferase; EC 2.4.2.12.). Moreover, reports on the structure and hormonal regulation of visfatin/PBEF/Nampt have given further insights into its potential physiological role. The present review summarizes studies on visfatin/PBEF/Nampt as a novel adipokine.Keywords
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