Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line
- 1 March 1985
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 314 (6009), 330-334
- https://doi.org/10.1038/314330a0
Abstract
Two genes that code for a hapten-specific immunoglobulin M (IgM) have been introduced into the mouse germ line. The transgenic antibody represents 10–50% of the serum IgM and is expressed on the membrane of B cells. B-cell hybridoma lines show that a negative feedback inhibition of μ and κ transgenic products on the immunoglobulin heavy-chain rearrangement is possible.This publication has 27 references indexed in Scilit:
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