Causes and consequences of nuclear gene positioning
- 1 January 2017
- journal article
- research article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 130 (9), 1501-1508
- https://doi.org/10.1242/jcs.199786
Abstract
The eukaryotic genome is organized in a manner that allows folding of the genetic material in the confined space of the cell nucleus, while at the same time enabling its physiological function. A major principle of spatial genome organization is the non-random position of genomic loci relative to other loci and to nuclear bodies. The mechanisms that determine the spatial position of a locus, and how position affects function, are just beginning to be characterized. Initial results suggest that there are multiple, gene-specific mechanisms and the involvement of a wide range of cellular machineries. In this Commentary, we review recent findings from candidate approaches and unbiased screening methods that provide initial insight into the cellular mechanisms of positioning and their functional consequences. We highlight several specific mechanisms, including tethering of genome regions to the nuclear periphery, passage through S-phase and histone modifications, that contribute to gene positioning in yeast, plants and mammals.Keywords
Funding Information
- National Institutes of Health
This publication has 70 references indexed in Scilit:
- Single-Cell Dynamics of Genome-Nuclear Lamina InteractionsCell, 2013
- LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate DifferentiationCell, 2013
- Step-Wise Methylation of Histone H3K9 Positions Heterochromatin at the Nuclear PeripheryCell, 2012
- DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear LaminaCell, 2012
- Transcription Factor Binding to a DNA Zip Code Controls Interchromosomal Clustering at the Nuclear PeripheryDevelopmental Cell, 2012
- An Epigenetic Signature for Monoallelic Olfactory Receptor ExpressionCell, 2011
- The role of nuclear pores in gene regulation, development and diseaseEMBO Reports, 2009
- The Meaning of Gene PositioningCell, 2008
- Variation in FTO contributes to childhood obesity and severe adult obesityNature Genetics, 2007
- A novel multigene family may encode odorant receptors: A molecular basis for odor recognitionCell, 1991