Databases in the area of pharmacogenetics
Open Access
- 1 February 2011
- journal article
- review article
- Published by Hindawi Limited in Human Mutation
- Vol. 32 (5), 526-531
- https://doi.org/10.1002/humu.21454
Abstract
In the area of pharmacogenetics and personalized health care it is obvious that databases, providing important information of the occurrence and consequences of variant genes encoding drug metabolizing enzymes, drug transporters, drug targets, and other proteins of importance for drug response or toxicity, are of critical value for scientists, physicians, and industry. The primary outcome of the pharmacogenomic field is the identification of biomarkers that can predict drug toxicity and drug response, thereby individualizing and improving drug treatment of patients. The drug in question and the polymorphic gene exerting the impact are the main issues to be searched for in the databases. Here, we review the databases that provide useful information in this respect, of benefit for the development of the pharmacogenomic field. Hum Mutat 32:1–6, 2011.Keywords
This publication has 41 references indexed in Scilit:
- PharmGKB summaryPharmacogenetics and Genomics, 2011
- Using text to build semantic networks for pharmacogenomicsJournal of Biomedical Informatics, 2010
- Reduced-Function CYP2C19 Genotype and Risk of Adverse Clinical Outcomes Among Patients Treated With Clopidogrel Predominantly for PCIJAMA, 2010
- Clinical assessment incorporating a personal genomeThe Lancet, 2010
- The Pharmacogenomics of Membrane Transporters Project: Research at the Interface of Genomics and Transporter PharmacologyClinical Pharmacology & Therapeutics, 2009
- Nomenclature for alleles of the cytochrome P450 oxidoreductase genePharmacogenetics and Genomics, 2009
- New feature: pathways and important genes from PharmGKBPharmacogenetics and Genomics, 2009
- Generating Genome-Scale Candidate Gene Lists for PharmacogenomicsClinical Pharmacology & Therapeutics, 2009
- Estimation of the Warfarin Dose with Clinical and Pharmacogenetic DataNew England Journal of Medicine, 2009
- Changes in consensus arylamine N-acetyltransferase gene nomenclaturePharmacogenetics and Genomics, 2008