Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease
- 24 February 2012
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 71 (6), 850-854
- https://doi.org/10.1002/ana.23568
Abstract
Somatic mutations in mitochondrial DNA (mtDNA) are hypothesized to play a role in Parkinson disease (PD), but large increases in mtDNA mutations have not previously been found in PD, potentially because neurons with high mutation levels degenerate and thus are absent in late stage tissue. To address this issue, we studied early stage PD cases and cases of incidental Lewy body disease (ILBD), which is thought to represent presymptomatic PD. We show for the first time that mtDNA mutation levels in substantia nigra neurons are significantly elevated in this group of early PD and ILBD cases. Ann Neurol 2012;71:850–854This publication has 121 references indexed in Scilit:
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