Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors
Open Access
- 1 January 2005
- journal article
- research article
- Published by Taylor & Francis Ltd in Journal of Enzyme Inhibition and Medicinal Chemistry
- Vol. 20 (6), 557-568
- https://doi.org/10.1080/14756360500212399
Abstract
The microwave-assisted synthesis of a family of 2,8-substituted thiazoloquinazolinones is described. The preliminary evaluation of the antiproliferative activity and the capacity of these molecules to inhibit CDKs and GSK-3 are reported. A lead compound was identified, constituting a scaffold from which more potent inhibitors could be designed.Keywords
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