Localized Administration of Tissue Plasminogen Activator through the Ophthalmic Artery in the Setting of Central Retinal Artery Occlusion

Abstract

Treatment of central retinal artery occlusion (CRAO) has been an ambiguous entity in the medical community. Many interventions have been explored; however, a standard of care has yet to be defined. Recent studies have suggested localized intra-arterial fibrinolysis as a promising method; however, a timeframe for optimal treatment initiation continues to be investigated. This case demonstrates an instance of CRAO treated with local fibrinolysis, however, what could be due to delayed time-to-treat, final visual outcomes were unfavorable. In conjunction with supporting literature, we believe optimization of thrombolytic protocols should be sought after to facilitate successful treatment outcomes. In addition, we encourage community awareness of the signs and symptoms of CRAO in hopes that earlier patient presentations will lead to swifter interventions and overall preservation of ocular function.