Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration
- 7 August 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Molecular Neurobiology
- Vol. 38 (1), 78-100
- https://doi.org/10.1007/s12035-008-8036-x
Abstract
Calpain is a ubiquitous calcium-sensitive protease that is essential for normal physiologic neuronal function. However, alterations in calcium homeostasis lead to persistent, pathologic activation of calpain in a number of neurodegenerative diseases. Pathologic activation of calpain results in the cleavage of a number of neuronal substrates that negatively affect neuronal structure and function, leading to inhibition of essential neuronal survival mechanisms. In this review, we examine the mechanistic underpinnings of calcium dysregulation resulting in calpain activation in the acute neurodegenerative diseases such as cerebral ischemia and in the chronic neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis, prion-related encephalopathy, and amylotrophic lateral sclerosis. The premise of this paper is that analysis of the signaling and transcriptional consequences of calpain-mediated cleavage of its various substrates for any neurodegenerative disease can be extrapolated to all of the neurodegenerative diseases vulnerable to calcium dysregulation.Keywords
This publication has 175 references indexed in Scilit:
- A study of phospholipids by ion mobility TOFMSJournal of the American Society for Mass Spectrometry, 2008
- Increased calpain correlates with Th1 cytokine profile in PBMCs from MS patientsJournal of Neuroimmunology, 2007
- The parkinsonian neurotoxin rotenone activates calpain and caspase-3 leading to motoneuron degeneration in spinal cord of Lewis ratsNeuroscience, 2007
- Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cellsBiochemical and Biophysical Research Communications, 2006
- μ-Calpain is functionally required for α-processing of Alzheimer’s β-amyloid precursor proteinBiochemical and Biophysical Research Communications, 2005
- Preserved synaptic vesicle recycling in hippocampal neurons in a mouse Alzheimer’s disease modelBiochemical and Biophysical Research Communications, 2005
- Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in BrainScience, 1997
- Modulation of inhibitory efficiency of rat skeletal muscle calpastatin by phosphorylationBiochemical and Biophysical Research Communications, 1992
- Calcium-activated neutral protease (CANP), a putative processing enzyme of the neuropeptide, kyotorphin, in the brainBiochemical and Biophysical Research Communications, 1988
- Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidaseBiochemical and Biophysical Research Communications, 1984