Prolongation of Rat Islet Allograft Survival by Direct Ultraviolet Irradiation of the Graft
- 10 February 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 223 (4636), 607-609
- https://doi.org/10.1126/science.6420888
Abstract
Ultraviolet irradiation of rat dendritic cells completely abrogated their allostimulatory capacity in a mixed lymphocyte reaction. Rat islets of Langerhans similarly irradiated remained hormonally functional when transplanted into syngeneic diabetic rats. Allogeneic transplantation across a major histocompatibility barrier of islets initially treated in vitro with ultraviolet irradiation resulted in prolonged allograft survival without the use of any immunosuppressive agents.This publication has 24 references indexed in Scilit:
- Pancreatic Islet Allograft Prolongation by Donor-Specific Blood Transfusions Treated with Ultraviolet IrradiationScience, 1983
- Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in miceThe Journal of Experimental Medicine, 1983
- CHARACTERIZATION OF LYMPHOCYTES FROM REJECTED AND NONREJECTED ISLET XENOGRAFTSTransplantation, 1982
- Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.The Journal of Experimental Medicine, 1982
- IMPAIRMENT OF ANTIGEN-PRESENTING CELL FUNCTION BY ULTRAVIOLET RADIATION II. EFFECT OF IN VITRO ULTRAVIOLET IRRADIATION ON ANTIGEN-PRESENTING CELLSTransplantation, 1981
- The influence of ultraviolet light irradiation on the immune systemClinical Immunology and Immunopathology, 1980
- Generation of T Memory Cells in One‐Way Mixed Lymphocyte CultureScandinavian Journal of Immunology, 1976
- Activation of Transplant Immunity: Effect of Donor Leukocytes on Thyroid Allograft RejectionScience, 1976
- IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICEThe Journal of Experimental Medicine, 1974
- Inability of UV-Irradiated Lymphocytes to Stimulate Allogeneic Cells in Mixed Lymphocyte CultureInternational Archives of Allergy and Immunology, 1971