Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study
Top Cited Papers
- 1 August 2013
- journal article
- research article
- Published by S. Karger AG in Skin Pharmacology and Physiology
- Vol. 27 (1), 47-55
- https://doi.org/10.1159/000351376
Abstract
Various dietary supplements are claimed to have cutaneous anti-aging properties; however, there are a limited number of research studies supporting these claims. The objective of this research was to study the effectiveness of collagen hydrolysate (CH) composed of specific collagen peptides on skin biophysical parameters related to cutaneous aging. In this double-blind, placebo-controlled trial, 69 women aged 35-55 years were randomized to receive 2.5 g or 5.0 g of CH or placebo once daily for 8 weeks, with 23 subjects being allocated to each treatment group. Skin elasticity, skin moisture, transepidermal water loss and skin roughness were objectively measured before the first oral product application (t0) and after 4 (t1) and 8 weeks (t2) of regular intake. Skin elasticity (primary interest) was also assessed at follow-up 4 weeks after the last intake of CH (t3, 4-week regression phase). At the end of the study, skin elasticity in both CH dosage groups showed a statistically significant improvement in comparison to placebo. After 4 weeks of follow-up treatment, a statistically significantly higher skin elasticity level was determined in elderly women. With regard to skin moisture and skin evaporation, a positive influence of CH treatment could be observed in a subgroup analysis, but data failed to reach a level of statistical significance. No side effects were noted throughout the study.Keywords
This publication has 43 references indexed in Scilit:
- Collagen Hydrolysate Intake Increases Skin Collagen Expression and Suppresses Matrix Metalloproteinase 2 ActivityJournal of Medicinal Food, 2011
- Age‐related changes in skin mechanical properties: a quantitative evaluation of 120 female subjectsSkin Research and Technology, 2011
- Clinical, biometric and structural evaluation of the long‐term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skinExperimental Dermatology, 2008
- Comparison of Quantity and Structures of Hydroxyproline-Containing Peptides in Human Blood after Oral Ingestion of Gelatin Hydrolysates from Different SourcesJournal of Agricultural and Food Chemistry, 2007
- Investigation of jumbo squid (Dosidicus gigas) skin gelatin peptides for their in vitro antioxidant effectsLife Sciences, 2005
- Identification of Food-Derived Collagen Peptides in Human Blood after Oral Ingestion of Gelatin HydrolysatesJournal of Agricultural and Food Chemistry, 2005
- Comparative study of the physiological properties of collagen, gelatin and collagen hydrolysate as cosmetic materialsInternational Journal of Cosmetic Science, 2005
- Vitamin A Antagonizes Decreased Cell Growth and Elevated Collagen-Degrading Matrix Metalloproteinases and Stimulates Collagen Accumulation in Naturally Aged Human Skin1Journal of Investigative Dermatology, 2000
- Activation of fibroblast metabolism in a dermal and skin equivalent model: a screening test for activity of peptidesInternational Journal of Cosmetic Science, 1998
- Pathophysiology of Premature Skin Aging Induced by Ultraviolet LightThe New England Journal of Medicine, 1997