Muscle metabolism in fibromyalgia studied by P‐31 magnetic resonance spectroscopy during aerobic and anaerobic exercise
- 1 May 2003
- journal article
- research article
- Published by Taylor & Francis Ltd in Scandinavian Journal of Rheumatology
- Vol. 32 (3), 138-145
- https://doi.org/10.1080/03009740310002461
Abstract
Objective: To investigate mechanisms underlying the reduced work capacity of fibromyalgia (FM) patients were compared to healthy controls at specified workloads, using P‐31 magnetic resonance spectroscopy (MRS). Methods: The forearm flexor muscle group was examined with MRS at rest, at sub maximal and at maximal controlled dynamic work as well as at maximal isometric contraction. Aerobic fitness was determined by bicycle ergonometry. Results: Metabolite concentrations and muscle pH were similar for patients and controls at lower workloads. At maximal dynamic and static contractions the concentration of inorganic phosphate was lower and at static contractions the pH decrease was smaller in patients. The performed work by patients was only 50% compared to controls and the patients experienced more pain. Maximal oxygen uptake was lower in the fibromyalgia group. Expired gas‐analysis in this group showed ventilatory equivalents at similar relative levels of maximal work capacity. Conclusion: Fibromyalgia patients seem to utilise less of the energy rich phosphorous metabolites at maximal work despite pH reduction. They seemed to be less aerobic fitted and reached the anaerobic threshold earlier than the controls.Keywords
This publication has 14 references indexed in Scilit:
- Neuroendocrine mechanisms in fibromyalgia–chronic fatigueBest Practice & Research Clinical Rheumatology, 2001
- Lack of association between fibromyalgia syndrome and abnormalities in muscle energy metabolismArthritis & Rheumatism, 1994
- Chronic pain after soft-tissue injury of the cervical spine: trapezius muscle blood flow and electromyography at static loads and fatiguePain, 1994
- Changes in muscle morphology in chronic trapezius myalgia.Scandinavian Journal of Work, Environment & Health, 1991
- The american college of rheumatology 1990 criteria for the classification of fibromyalgiaArthritis & Rheumatism, 1990
- Increased EMG Activity during Short Pauses in Patients with Primary FibromyalgiaScandinavian Journal of Rheumatology, 1989
- Cerebral intracellular pH by 31 P nuclear magnetic resonance spectroscopyNeurology, 1985
- Reference values for exercise tests with continuous increase in loadClinical Physiology and Functional Imaging, 1985