Synthesis and Study of Cross-Linked Chitosan-N-Poly(ethylene glycol) Nanoparticles
- 19 October 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 7 (11), 3030-3036
- https://doi.org/10.1021/bm0605053
Abstract
The present investigation describes the synthesis and characterization of novel biodegradable nanoparticles based on chitosan. Poly(ethylene glycol) dicarboxylic acid was used for intramolecular cross-linking of the chitosan linear chains. The condensation reaction of carboxylic groups and pendant amino groups of chitosan was performed by using water-soluble carbodiimide. The prepared nanosystems were stable in aqueous media. The structure of the products was determined by nuclear magnetic resonance (NMR) spectroscopy, and the particle size was identified by dynamic light scattering (DLS) and transmission electron microscopy (TEM) measurements. It was found that biodegradable cross-linked chitosan nanoparticles experienced considerable swelling because of the length and flexibility of the cross-linking agent. The aqueous solutions or dispersions of nanoparticles were stable and clear or mildly opalescent systems depending on the ratio of cross-linking and molecular weight of chitosan, findings consistent with values of transmittance above 75%. Particle size measured by TEM varied in the range of 4-24 nm. In the swollen state, the average size of the individual particles measured by DLS was in the range of 50-120 nm depending on the molecular weight of chitosan and the ratio of cross-linking.Keywords
This publication has 27 references indexed in Scilit:
- Synthesis of Novel Quaternary Chitosan Derivatives via N-Chloroacyl-6-O-triphenylmethylchitosansBiomacromolecules, 2005
- Preparation and Characterization of Chitosan-Based NanoparticlesBiomacromolecules, 2005
- Recent developments in polysaccharide-based materials used as adsorbents in wastewater treatmentProgress in Polymer Science, 2005
- Preparation of sub-micrometer porous membrane from chitosan/polyethylene glycol semi-IPNJournal of Membrane Science, 2004
- Recent advances on chitosan-based micro- and nanoparticles in drug deliveryJournal of Controlled Release, 2004
- Synthesis and characterization of cross-linked chitosan membranes for application as alternative proton exchange membrane materials in fuel cellsJournal of Power Sources, 2004
- Reaction kinetics and gel properties of blocked diisocyinate crosslinked chitosan hydrogelsCarbohydrate Polymers, 2003
- Chitosans for gene deliveryAdvanced Drug Delivery Reviews, 2001
- Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugsJournal of Controlled Release, 1996
- Permeability and blood compatibility properties of chitosan-poly(ethylene oxide) blend membranes for haemodialysisBiomaterials, 1995