Digitalis-associated cardiac mortality after myocardial infarction.
- 1 December 1981
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Cell Metabolism
- Vol. 64 (6), 1150-1156
- https://doi.org/10.1161/01.cir.64.6.1150
Abstract
The effect of digitalis therapy on 4-month posthospital cardiac mortality was investigated in 812 patients who survived the hospital phase of acute myocardial infraction. A stepwise multiple logistic regression analysis was used to identify variables associated with increased mortality and to adjust for differences in confounding variables between digitalis and nondigitalis patients. The major 4-month mortality (10 of 26 patients [38.5%]) occurred in digitalis-treated patients with congestive heart failure in the coronary care unit and complex ventricular premature depolarizations (VPDs) on the predischarge Holter recording. Logistic analyses that controlled for confounding variables indicated that digitalis use contributed to the increased mortality rate in this high-risk subset. The predicted mortality difference due to digitalis in patients with congestive heart failure and complex VPDs, adjusted for relevant nondigitalis risk factor variables, was 30% (90% confidence interval 18-42%). This retrospective study suggests that digitalis use increases the early posthospital mortality of myocardial infarction patients with combined electrical and mechanical dysfunction.This publication has 14 references indexed in Scilit:
- Survivorship patterns in the posthospital phase of myocardial infarction.Circulation, 1979
- Digoxin-Quinidine InteractionNew England Journal of Medicine, 1979
- IS MAINTENANCE DIGOXIN NECESSARY IN PATIENTS WITH SINUS RHYTHM?The Lancet, 1979
- DISCONTINUATION OF MAINTENANCE DIGOXIN THERAPY IN GENERAL PRACTICEThe Lancet, 1977
- The early posthospital phase of myocardial infarction. Prognostic stratification.Circulation, 1976
- DigitalisNew England Journal of Medicine, 1973
- Biochemical "Defect" in the Hypertrophied and Failing HeartCirculation, 1973
- Electrocardiographic classification for population comparisonsJournal of Electrocardiology, 1969