Roles of dietary fat and fibre in the disposition and metabolism of carcinogens associated with foods

Abstract

The abilities of dietary fibre (wheat bran) or fat (olive oil) to modify the genotoxicity of radiolabelled MelQ were evaluated in mice using in vivo and in vitro bacterial mutation assays. Bran reduced genotoxicity by restricting uptake of MelQ from the gut lumen. In contrast, feeding mice a high fat diet led to increased hepatic conversion of MelQ to an active genotoxin.