Rapid Expansion of Intravitreal Drug Injection Procedures, 2000 to 2008

Abstract
The development of vascular endothelial growth factor (VEGF) inhibitors has revolutionized the treatment of age-related macular degeneration (AMD), the leading cause of blindness in Western nations.1-3 The Minimally Classic/Occult Trial of the Anti-VEGF Antibody Ranibizumab in the Treatment of Neovascular AMD2 and the Anti-VEGF Antibody for the Treatment of Predominantly Classic Choroidal Neovascularization in AMD trial3 have demonstrated that the VEGF inhibitor ranibizumab not only slows vision loss but also improves visual acuity in many patients with neovascular AMD.