Hospital-Based Surveillance for Japanese Encephalitis at Four Sites in Bangladesh, 2003–2005
- 1 February 2010
- journal article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 82 (2), 344-349
- https://doi.org/10.4269/ajtmh.2010.09-0125
Abstract
We investigated the epidemiology and etiology of encephalitis at four tertiary hospitals in Bangladesh during 2003–2005. Patients who met a clinical case definition for acute encephalitis and had cerebrospinal fluid (CSF) pleocytosis were eligible for enrollment; a standardized sampling pattern was used to enroll eligible patients. Recent Japanese encephalitis virus (JEV) infection was defined by presence of IgM antibodies against JEV in CSF or serum. Twenty (4%) of 492 cases had laboratory evidence of recent JEV infection; two died. All JE cases occurred during May–December, and cases were identified among all age groups. All cases resided in rural areas. Fifteen patients were re-assessed 4–6 weeks after hospitalization; 5 (33%) patients had physical disabilities and 7 (47%) reported cognitive difficulties. Infection with JEV is clearly an etiology of encephalitis in Bangladesh. Population-based studies to quantify burden of disease could assess options for targeted immunization programs.This publication has 22 references indexed in Scilit:
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