Guidelines for prescribing melatonin
- 1 January 1998
- journal article
- review article
- Published by Informa UK Limited in Annals of Medicine
- Vol. 30 (1), 122-130
- https://doi.org/10.3109/07853899808999394
Abstract
Although compelling logic suggests that melatonin may be effective for a variety of disorders, there are few empirical clinical studies. The optimal dose of melatonin is not clear; most studies have used doses that produce supraphysiological blood levels. The timing of melatonin administration is important. Melatonin has few immediate side-effects except drowsiness, but the effects of chronic administration are unclear. Melatonin may be effective in reducing jet lag. In elderly patients with poor sleep and documented low melatonin production, melatonin may be helpful. In several studies, melatonin has been shown to shorten sleep latency. Further studies are needed to clarify the efficacy and safety of melatoninKeywords
This publication has 61 references indexed in Scilit:
- Daytime melatonin administration enhances sleepiness and theta/alpha activity in the waking EEGNeuroscience Letters, 1996
- Melatonin and insomniaJournal of Sleep Research, 1996
- Rapid cycling in severely multidisabled children: A form of bipolar affective disorder?Pediatric Neurology, 1994
- Effects of melatonin on pulmonary and coronary vessels are exerted through perivascular nervesClinical Autonomic Research, 1993
- The Influence of Intravenous L-Tryptophan on Plasma Melatonin and Sleep in MenPharmacopsychiatry, 1991
- Some effects of jet-lag and their alleviation by melatoninErgonomics, 1987
- Circadian temperature rhythms in young adult and aged menNeurobiology of Aging, 1986
- Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjectsPsychoneuroendocrinology, 1983
- Light Suppresses Melatonin Secretion in HumansScience, 1980
- On the effect of melatonin upon human brain. Its possible therapeutic implicationsLife Sciences, 1971