One hundred children with primary pyoderma and 50 healthy children were included in the study. The swabs collected from the lesions were cultured on various media. The colonies were identified by conventional methods. Commonest isolate was Staph. aureus (45%), followed by Strep. pyogens (35%), E. coli (5%), Citrobacter (1%) and Staph. and Strept. together (14%). Staphylococci showed highest resistance to ampicillin (85%), followed by penicillin (78%), tetracycline (40%) and ciprofloxacin (15%). Streptococci and other Gram-negative isolates were sensitive to most of the drugs. Most strains of staphylococci were nontypable (42.2%) suggesting the possible emergence of new strains. Among typable ones, phage group-1 was commonest.